Route 40 – Argentina North to South
Departure
Over 3,350 miles crossing Argentina from north to south, from La Quiaca all the way to Cabo Vírgenes, aboard 4×4 trucks with a live musical itinerary. Route 40 like you’ve never experienced it before.
Highlights
- The complete Route 40: from La Quiaca to Cabo Vírgenes — Argentina’s most iconic road driven in its entirety.
- Live musical itinerary: musician Martín Marassa joins the entire journey, performing iconic songs from each region on guitar.
- 20 included excursions: the Train to the Clouds, Perito Moreno Glacier, Cueva de las Manos, Talampaya National Park, El Chaltén, and much more.
- 4×4 travel: the entire route in Toyota Hilux trucks, in groups of 3 passengers per vehicle.
- Extraordinary landscapes: arid Puna highlands, Calchaquí Valleys, volcanic pumice deserts, red rock canyons, turquoise lakes, ancient forests, and Patagonian glaciers.
- Option to do the trip in 2 separate stages: Route 40 North (La Quiaca–Mendoza) or Route 40 South (Mendoza–Cabo Vírgenes).
Departure – October 13, 2026 · Only 6 spots available
Get ready to drive Argentina’s Route 40 from north to south like you’ve never done it before. Over 3,350 miles through landscapes that look like they belong to another planet: the quiet, arid Puna highlands of the north, the Calchaquí Valleys bursting with vineyards and earthy colors, white volcanic pumice deserts, the red canyons of Talampaya, and on into the wildest Patagonia — turquoise lakes, ancient forests, and towering glaciers.
Each leg of the journey is a show of colors, cultures, and traditions: Andean villages with ancestral folklore, indigenous communities keeping living roots alive, colonial towns that seem frozen in time, and cities that blend history and modernity. The cultural richness is felt at every stop, and the sheer diversity of landscapes will make you feel like you’re traveling through several countries without leaving Argentina.
What makes this trip truly one of a kind is its live musical itinerary. Musician Martín Marassa joins the entire adventure, playing iconic songs from each region on guitar — every song chosen so you connect deeply with the place you’re moving through.
The full journey is traveled in 4×4 Toyota Hilux trucks, with 3 passengers per vehicle, ensuring comfort and access to the most remote corners of the country.
💰 Price per person (double occupancy): USD 7,650
Can’t do the full route?
You can also join one of the two stages separately:
13 nights · Same itinerary
USD 3.600 per person, double occupancy with breakfast
16 nights · Same itinerary
Our Upcoming Destinations
Daily Itinerary
Date: October 13
Domestic flight from Córdoba to San Salvador de Jujuy. The great journey begins.
Date: October 14
Breakfast and drive to La Quiaca (175 mi): the northern starting point of Route 40. From here our journey begins all the way to its southern end at Cabo Vírgenes, Santa Cruz.
📍 175 mi (282 km)
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- Wild Guanaco (Lama Guanicoe) in Patagonia prairie, Chile, South America
Date: October 15
85 miles to Cusi Cusi. Visit to the Valley of the Moon (Jujuy version).
📍 85 mi (137 km)
★ Valley of the Moon
Date: October 16
112 miles to Susques: a small Puna village at over 11,800 feet above sea level, surrounded by arid landscapes and volcanoes.
📍 112 mi (180 km) · 11,800 ft
🌙 Overnight: Susques
Date: October 17
79 miles to San Antonio de los Cobres: a high-altitude town in the Salta Puna, famous for the Train to the Clouds route and its extreme landscapes. Included excursion: Train to the Clouds.
📍 79 mi (127 km)
★ Train to the Clouds
🌙 Overnight: San Antonio de los Cobres
Date: October 18
90 miles to Cachi: a charming colonial village nestled in the Calchaquí Valleys.
📍 90 mi (145 km)
🌙 Overnight: Cachi
Date: October 19
97 miles to Cafayate. Visit to its famous rock formations including the Amphitheater, followed by a tour of a local winery.
📍 97 mi (156 km)
★ Amphitheater ★ Winery tour
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- Beautiful deserted landscapes in Cafayate region, Argentina, South America
Date: October 20
On the way to Belén, we visit Amaicha and the Quilmes Ruins (Tucumán): a territory with deep, living indigenous roots.
★ Quilmes Ruins
Date: October 21
Excursion to the Pumice Stone Field: a breathtaking white volcanic desert sculpted by the wind into a landscape unlike anything else on Earth.
★ Pumice Stone Field
🌙 Overnight: Belén
Date: October 22
145 miles through Famatina: mining history, mountain scenery, and La Rioja tradition. Ride the Chilecito cable car.
📍 145 mi (233 km)
★ Chilecito Cable Car
Date: October 23
156 miles along the scenic Cuesta de Miranda pass, then a detour into Talampaya National Park: one of Argentina's most dramatic landscapes, with canyon walls reaching 500 feet high.
📍 156 mi (251 km)
★ Talampaya National Park
Date: October 24 & 25
204 miles to Mendoza: a vibrant city set between vineyards and the Andes. The exact midpoint of the journey.
- Oct 24: Arrival and free afternoon
- Oct 25: Big Bus city tour and free afternoon
📍 204 mi (328 km)
★ Big Bus Mendoza
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- Organic vineyards near Mendoza in Argentina with Andes in the background
Date: October 26
202 miles to Malargüe: gateway to southern Mendoza, known for its arid landscapes and unique geology. Visit to the Planetarium. 📍 202 mi (325 km) ★ Planetarium
Date: October 27
208 miles to Chos Malal: a Neuquén city with a mining history, surrounded by mountains and rivers. Visit to Malacara Volcano.
📍 208 mi (335 km)
★ Malacara Volcano
Date: October 28
284 miles to the stunning San Martín de los Andes: a mountain resort town in Neuquén surrounded by lakes and forests. Free afternoon to enjoy the village.
📍 284 mi (457 km)
Date: October 29
Boat tour on Lake Lácar: crystal-clear water surrounded by mountains and araucaria forests.
★ Lake Lácar Boat Tour
Date: October 30
180 miles through Villa La Angostura: visit to the Arrayanes Forest and a boat ride on Nahuel Huapi Lake. Continue on to Bariloche.
📍 180 mi (290 km)
★ Arrayanes Forest ★ Nahuel Huapi Lake Tour
Date: October 31
City tour of Bariloche: the iconic Río Negro city famous for its lakes and mountain peaks. Visit to Catedral Hill. ★ City Tour + Catedral Hill
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- Stunning views of Lake District from viewpoint on top of Cerro Campanario, Argentina
Date: November 1
220 miles to Esquel and entry into Los Alerces National Park, home to ancient alerce trees over 2,600 years old.
📍 220 mi (354 km)
★ Los Alerces National Park
Date: November 2
Mapuche Community. Visit to the tulip fields in Trevelin (if still in bloom).
★ La Trochita ★ Tulip Fields
Date: November 3
255 miles to Río Mayo: a small Chubut town surrounded by rivers and Patagonian plateaus.
📍 255 mi (411 km)
Date: November 4
193 miles to Posta de los Toldos. Visit to the Cave of the Hands, a UNESCO World Heritage Site with rock paintings over 9,000 years old.
📍 193 mi (311 km)
★ Cave of the Hands (UNESCO)
Date: November 5 and 6
334 miles to El Chaltén: Argentina's trekking capital, surrounded by iconic peaks like Mount Fitz Roy. Guided hiking activity.
📍 334 mi (537 km)
★ Guided Hiking in El Chaltén
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- A stunning view of Cerro Fitz Roy above the town of El Chalten in Santa Cruz, Argentina
Date: November 7 & 8
132 miles to El Calafate: land of glaciers and dazzling Patagonian scenery.
- Day 26: Arrival and free afternoon
- Day 27: Excursion to the Perito Moreno Glacier — walk on the ice and marvel at the massive, ever-moving glacier up close
📍 132 mi (213 km) ★ Perito Moreno Glacier
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- The Grey Glacier in Torres del Paine National Park in the Southern Patagonian Ice Field in Patagonia, southern Chile
Date: November 9
310 miles to Río Gallegos via Río Turbio — the final long drive through Patagonia.
📍 310 mi (499 km)
Date: November 10
Visit to Cabo Vírgenes: the southern endpoint of Route 40, at the far tip of Santa Cruz. Historic lighthouse and a Magellanic penguin colony. Return to Río Gallegos and transfer to the airport. Night flight.
★ Cabo Vírgenes – End of Route 40
Date: November 11
Return flight home. The end of a journey through the full soul of Argentina.
Included
- Domestic flights (round trip)
- Full 3,355-mile route in 4x4 Toyota Hilux trucks (3 passengers each)
- 28 nights accommodation with breakfast (*)
- 20 excursions and activities
- Live musical itinerary by Martín Marassa
- Permanent accompaniment by the Andante team
Not Included
- Travel insurance (required)
- Tips for local guides
- Anything not listed under "Included"
